What it does:Stimulates cell growthIncreases cell

Lasers Surg Med 21:485-92.Klotz LO, Kroncke KD, and Sies H. 2003. Singlet oxygen-induced signaling effects in mammaliancells. Photochem Photobiol Sci 2:88-94.Kreisler M, Christoffers AB, Willershausen B, and d'Hoedt B. 2003. Effect of low-level GaAlAs laserirradiation on the proliferation rate of human periodontal ligament fibroblasts: an in vitrostudy. J Clin Periodontol 30:353-8.Biphasic dose response in low level light therapyLampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, Borenstein P, Andersson B, Perez J, CaparoC, Ilic S, and Oron U. 2007. Infrared Laser Therapy for Ischemic Stroke: A New TreatmentStrategy. Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). StrokeLane N. 2006. Cell biology: power games. Nature 443:901-3.Lane P and Gross SS. 1999. Cell signaling by nitric oxide. Semin Nephrol 19:215-29.Lanzafame RJ, Stadler I, Kurtz AF, Connelly R, Peter TA, Sr., Brondon P, and Olson D. 2007.Reciprocity of exposure time and irradiance on energy density during photoradiation onwound healing in a murine pressure ulcer model. Lasers Surg Med 39:534-42.Lapchak PA, Han MK, Salgado KF, Streeter J, and Zivin JA. 2008. Safety profile of transcranial nearinfraredlaser therapy administered in combination with thrombolytic therapy to embolized rabbits.Stroke 39:3073-8.Lavi R, Shainberg A, Friedmann H, Shneyvays V, Rickover O, Eichler M, Kaplan D, and Lubart R.2003. Low energy visible light induces reactive oxygen species generation and stimulates anincrease of intracellular calcium concentration in cardiac cells. J Biol Chem 278:40917-22.Leal Junior EC, Lopes-Martins RA, Baroni BM, De Marchi T, Taufer D, Manfro DS, Rech M, DannaV, Grosselli D, Generosi RA, Marcos RL, Ramos L, and Bjordal JM. 2008a. Effect of 830 nm lowlevellaser therapy applied before high-intensity exercises on skeletal muscle recovery in athletes.Lasers Med SciLeal Junior EC, Lopes-Martins RA, Vanin AA, Baroni BM, Grosselli D, De Marchi T, Iversen VV, andBjordal JM. 2008b. Effect of 830 nm low-level laser therapy in exercise-induced skeletal musclefatigue in humans. Lasers Med SciLoevschall H and Arenholt-Bindslev D. 1994. Effect of low level diode laser irradiation of human oralmucosa fibroblasts in vitro. Lasers Surg Med 14:347-54.Lopes-Martins RA, Albertini R, Martins PS, Bjordal JM, and Faria Neto HC. 2005. Spontaneous effectsof low-level laser therapy (650 nm) in acute inflammatory mouse pleurisy induced byCarrageenan. Photomed Laser Surg 23:377-81.Lubart R, Eichler M, Lavi R, Friedman H, and Shainberg A. 2005. Low-energy laser irradiation promotescellular redox activity. Photomed Laser Surg 23:3-9.Lubart R, Lavi R, Friedmann H, and Rochkind S. 2006. Photochemistry and photobiology of lightabsorption by living cells. Photomed Laser Surg 24:179-85.Lubart R, Wollman Y, Friedmann H, Rochkind S, and Laulicht I. 1992. Effects of visible and nearinfraredlasers on cell cultures. J Photochem Photobiol B 12:305-10.Martius F. 1923. Das Amdt-Schulz Grandgesetz. Munch Med Wschr 70:1005-1006.Mester E, Nagylucskay S, Waidelich W, Tisza S, Greguss P, Haina D, and Mester A. 1978. Effects ofdirect laser radiation on human lymphocytes. Arch Dermatol Res 263:241-5.Mester E, Szende. B. and Tota, J.G. 1967. Effect of laser on hair growth of mice. Kiserl Orvostud19:628-631.Mitka M. 1998. 1998 NObel Prize winners are announced: three discoverers of nitric oxide activity.Jama 280:1648.Moore P, Ridgway TD, Higbee RG, Howard EW, and Lucroy MD. 2005. Effect of wavelength on lowintensitylaser irradiation-stimulated cell proliferation in vitro. Lasers Surg Med 36:8-12.Morrone G, Guzzardella GA, Torricelli P, Rocca M, Tigani D, Brodano GB, Fini M, and Giardino R.2000. Osteochondral lesion repair of the knee in the rabbit after low-power diode Ga-Al-As laserbiostimulation: an experimental study. Artif Cells Blood Substit Immobil Biotechnol 28:321-36.Oron A, Oron U, Streeter J, de Taboada L, Alexandrovich A, Trembovler V, and Shohami E. 2007.low-level laser therapy applied transcranially to mice following traumatic brain injury significantlyreduces long-term neurological deficits. J Neurotrauma 24:651-6.Oron U, Yaakobi T, Oron A, Hayam G, Gepstein L, Rubin O, Wolf T, and Ben Haim S. 2001a.Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation.Lasers Surg Med 28:204-11.Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R, Hayam G, Dror U, Gepstein L, Wolf T,Haudenschild C, and Haim SB. 2001b. Low-energy laser irradiation reduces formation of scartissue after myocardial infarction in rats and dogs. Circulation 103:296-301.Ozcelik O, Cenk Haytac M, Kunin A, and Seydaoglu G. 2008. Improved wound healing by low-levellaser irradiation after gingivectomy operations: a controlled clinical pilot study. J ClinPeriodontol 35:250-4.Y.-Y. Huang and othersOzdemir F, Birtane M, and Kokino S. 2001. The clinical efficacy of low-power laser therapy on painand function in cervical osteoarthritis. Clin Rheumatol 20:181-4.Pal G, Dutta A, Mitra K, Grace MS, Romanczyk TB, Wu X, Chakrabarti K, Anders J, Gorman E,Waynant RW, and Tata DB. 2007. Effect of low intensity laser interaction with human skinfibroblast cells using fiber-optic nano-probes. J Photochem Photobiol B 86:252-61.Passarella S, Casamassima E, Molinari S, Pastore D, Quagliariello E, Catalano IM, and Cingolani A.1984. Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondriairradiated in vitro by helium-neon laser. FEBS Lett 175:95-9.Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, and Davies KJ. 2006. Free radicalbiology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol 291:R491-511.Rochkind S, Leider-Trejo L, Nissan M, Shamir MH, Kharenko O, and Alon M. 2007. Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure(double-blind randomized study). Photomed Laser Surg 25:137-43.Schreck R, Albermann K, and Baeuerle PA. 1992. Nuclear factor kappa B: an oxidative stress-responsivetranscription factor of eukaryotic cells (a review). Free Radic Res Commun 17:221-37.Schubert MM, Eduardo FP, Guthrie KA, Franquin JC, Bensadoun RJ, Migliorati CA, Lloid CM,Eduardo CP, Walter NF, Marques MM, and Hamdi M. 2007. A phase III randomized doubleblindplacebo-controlled clinical trial to determine the efficacy of low level laser therapy for theprevention of oral mucositis in patients undergoing hematopoietic cell transplantation. SupportCare Cancer 15:1145-54.Schulz H. 1877. Uber die Theorie der Arzneimittelwirkung. Virchows Archiv 108:423--434.Schulz H. 1888. Uber Hefegiste. Pflgers Archiv Gesammte Physiologie 42:517-541.Shao XH, Yang YP, Dai J, Wu JF, and Bo AH. 2005. Effects of He-Ne laser irradiation on chronicatrophic gastritis in rats. World J Gastroenterol 11:3958-61.Shefer G, Partridge TA, Heslop L, Gross JG, Oron U, and Halevy O. 2002. Low-energy laser irradiationpromotes the survival and cell cycle entry of skeletal muscle satellite cells. J Cell Sci115:1461-9.Shiva S and Gladwin MT. 2009. Shining a light on tissue NO stores: near infrared release of NO fromnitrite and nitrosylated hemes. J Mol Cell Cardiol 46:1-3.Sommer AP, Pinheiro AL, Mester AR, Franke RP, and Whelan HT. 2001. Biostimulatory windows inlow-intensity laser activation: lasers, scanners, and NASA's light-emitting diode array system. JClin Laser Med Surg 19:29-33.Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, and Lanzafame RJ. 2000. In vitro effects oflow-level laser irradiation at 660 nm on peripheral blood lymphocytes. Lasers Surg Med 27:255-61.Stebbing AR. 1982. Hormesis; the stimulation of growth by low levels of inhibitors. Sci Tot Environ22:213-234.Stelian J, Gil I, Habot B, Rosenthal M, Abramovici I, Kutok N, and Khahil A. 1992. Improvement ofpain and disability in elderly patients with degenerative osteoarthritis of the knee treated withnarrow-band light therapy. J Am Geriatr Soc 40:23-6.Stergioulas A, Stergioula M, Aarskog R, Lopes-Martins RA, and Bjordal JM. 2008. Effects of low-levellaser therapy and eccentric exercises in the treatment of recreational athletes with chronicachilles tendinopathy. Am J Sports Med 36:881-7.Storz P. 2007. Mitochondrial ROS--radical detoxification, mediated by protein kinase D. Trends CellBiol 17:13-8.Sutherland JC. 2002. Biological effects of polychromatic light. Photochem Photobiol 76:164-70.Tafur J and Mills PJ. 2008. Low-intensity light therapy: exploring the role of redox mechanisms.Photomed Laser Surg 26:323-8.Townsend JF and Luckey TD. 1960. Hormoligosis in pharmacology. J Am Med Assoc 173:44-48.Tumilty S, Munn J, McDonough S, Hurley DA, Basford JR, and Baxter GD. 2009. Low Level LaserTreatment of Tendinopathy: A Systematic Review with Meta-analysis Photomed Laser SurgAhead of print:Vasseljen O, Jr., Hoeg N, Kjeldstad B, Johnsson A, and Larsen S. 1992. Low level laser versus placeboin the treatment of tennis elbow. Scand J Rehabil Med 24:37-42.Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, and Oakley F. 2008. NFkappaBis a critical regulator of the survival of rodent and human hepatic myofibroblasts. JHepatol 48:589-97.Biphasic dose response in low level light therapyWeber JB, Pinheiro AL, de Oliveira MG, Oliveira FA, and Ramalho LM. 2006. Laser therapy improveshealing of bone defects submitted to autologous bone graft. Photomed Laser Surg 24:38-44.Wu S, Xing D, Gao X, and Chen WR. 2009. High fluence low-power laser irradiation induces mitochondrialpermeability transition mediated by reactive oxygen species. J Cell Physiol 218:603-11.Yaakobi T, Shoshany Y, Levkovitz S, Rubin O, Ben Haim SA, and Oron U. 2001. Long-term effect oflow energy laser irradiation on infarction and reperfusion injury in the rat heart. J Appl Physiol90:2411-9.Yamaura M, Yao M, Yaroslavsky I, Cohen R, Smotrich M, and Kochevar IE. 2009. Low level lighteffects on inflammatory cytokine production by rheumatoid arthritis synoviocytes. Lasers SurgMed 41:282-90.Yu W, Naim JO, and Lanzafame RJ. 1994. The effect of laser irradiation on the release of bFGF from3T3 fibroblasts. Photochem Photobiol 59:167-70.Yu W, Naim JO, and Lanzafame RJ. 1997. Effects of photostimulation on wound healing in diabeticmice. Lasers Surg Med 20:56-63.Zhang J, Xing D, and Gao X. 2008. Low-power laser irradiation activates Src tyrosine kinase throughreactive oxygen species-mediated signaling pathway. J Cell Physiol 217:518-28.Zhang Y, Song S, Fong CC, Tsang CH, Yang Z, and Yang M. 2003. cDNA microarray analysis of geneexpression profiles in human fibroblast cells irradiated with red light. J Invest Dermatol 120:849-57.Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, Fisher M, Hacke W, Holt W,Ilic S, Kasner S, Lew R, Nash M, Perez J, Rymer M, Schellinger P, Schneider D, Schwab S,Veltkamp R, Walker M, and Streeter J. 2009. Effectiveness and safety of transcranial laser therapyfor acute ischemic stroke. Stroke 40:1359-64